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10.1093/jxb/32.1.93 6 DingN.WangA.ZhangX.WuY.WangR.CuiH.et al (2017)

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For instance, copper is required for the activation of MEK1 kinase, and disruption of this copper-dependent signaling contributes directly to myofibrillar disorganization and pathological hypertrophy [182, 183]

70 There are three principle challenges associated with anti-IGF-1R hormonal therapy: (1) most of the anti-IGF-1R antibodies are reported to have minor responses, 86 (2) the therapy targeting IGF-1R causes hyperglycemia due either to disruption of GH homeostasis or direct inhibition of IR by TKIs, 87 and (3) chronic exposure to anti-IGF-1R might induce resistance

Glutathione present in human epithelial lining fluid is a key enzyme that protects the lungs from oxidative stress 51